METHODS AND COMPOSITIONS FOR REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS

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United States of America Patent

APP PUB NO 20120122217A1
SERIAL NO

13360148

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Abstract

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The present invention concerns methods and compositions involving the production or generation of siRNA mixtures or pools capable of triggering RNA-mediated interference (RNAi) in a cell. Compositions of the invention include kits that include reagents for producing or generating siRNA pools. The present invention further concerns methods using polypeptides with RNase III activity for generating siRNA mixtures or pools that effect RNAi, including the generation of a number of RNA molecules to the same target gene.

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Patent Owner(s)

Patent OwnerAddress
APPLIED BIOSYSTEMS LLCCARLSBAD CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brown, David Austin, US 445 8878
Ford, Lance P Austin, US 16 382
Jarvis, Rich Austin, US 30 978

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