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United States of America Patent

APP PUB NO 20120128632A1
SERIAL NO

13386456

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Abstract

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Methods for identifying trichogenic dermal cells, including dermal papilla cells and dermal sheath cells, capable of inducing hair follicle formation when injected into skin are provided. It has been discovered that EGF latrophilin and seven transmembrane domain-containing protein 1 (ELTD1). Transmembrane Protein 108 (TMEM1 08), Hyaluronan and proteoglycan link protein 1 (HAPLN1) are biomarkers that can be used to detect, identify, and distinguish trichogenic dermal cells, i.e., that are able to induce hair follicle formation, from other skin cells. Populations of skin cells enriched with trichogenic dermal cells can be produced by selecting for and enriching for dermal cells that express ELTD1, TMEM1 08, HAPLN1, or a combination thereof.

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Patent Owner(s)

Patent OwnerAddress
ADERANS RESEARCH INSTITUTE INC2211 NEWMARKET PARKWAY SUITE 142 MARIETTA GA 30067

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mastyugin, Vladimir Lexington, US 2 1
Qiao, Jizeng Lexington, US 5 35
Teumer, Jeffrey Keeler Brookline, US 4 44
Zawadzka, Agatha Essex, US 3 25

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