BIOMARKERS FOR THE PROGNOSIS AND HIGH-GRADE GLIOMA CLINICAL OUTCOME
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United States of America Patent
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Issued Date -
May 24, 2012
app pub date -
Sep 20, 2011
filing date -
Sep 20, 2010
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Abstract
The present invention relates to the identification and use of biomarkers with clinical relevance to high grade gliomas (HGGs). In particular, the invention provides the identity of four genes, CHAF1B, PDLIM4, EDNRB and HJURP, whose expression, at the transcriptome and proteome levels, is correlated with HGG grading and clinical survival outcome. Methods and kits are provided for using these biomarkers in the prognostication of HGGs, and in the selection and/or monitoring of treatment regimens.
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