HIGH BIOAVAILABILITY ORAL PICOPLATIN ANTI-CANCER THERAPY
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United States of America Patent
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Issued Date -
Jun 14, 2012
app pub date -
Mar 11, 2010
filing date -
Apr 15, 2009
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention provides a method of treatment of cancer, wherein a individual doses of picoplatin, each of less than about 200 mg picoplatin content, the individual doses having high oral bioavailability, are administered to a patient in need thereof. The oral bioavailability can be greater than about 50%, or greater than about 75%, or greater than about 90%, depending upon the particular dosage form and dosing regimen used. The invention provides a quasi-metronomic dosing schedule including drug dosing intervals and drug intermission intervals, optionally including fasting periods prior to and following administration of each individual dose of picoplatin.
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