NUCLEIC ACID MOLECULES AND USES THEREOF
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United States of America Patent
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Issued Date -
Jun 14, 2012
app pub date -
Aug 27, 2010
filing date -
Aug 27, 2009
priority date (Note) -
Abandoned
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Abstract
Provided in this application are formulations of double stranded RNA molecules and Krebs Cycle analogs that improving ribonuclease stability, reducing off-target effects of a double stranded siRNA molecule, or of reducing interferon responsiveness of a double stranded siRNA molecule using such dsRNA. Also disclosed are methods of treating a primary tumor or a metastasis by contacting circulating tumor cells, a primary tumor, or a metastasis with a described formulation.
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