EXPANDING THE T CELL REPERTOIRE TO INCLUDE SUBDOMINANT EPITOPES BY VACCINATION WITH ANTIGENS DELIVERED AS PROTEIN FRAGMENTS OR PEPTIDE COCKTAILS
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Dec 16, 2011
filing date -
Jun 28, 2006
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Abandoned
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Abstract
A convenient way of inducing a broad recognition of dominant and subdominant responses to epitopes of any given antigen of importance for prophylaxis or treatment of a chronic disease is provided. The method involves immunizing with pools of overlapping fragments (synthetic peptides, e.g., 10-30 mers with 2-20 aa overlap) of the desired antigen in appropriate adjuvants. The T cell repertoire is primed to include not only the immunodominant epitope recognized when the intact molecule is used for immunization and induced by the chronic infection itself, but induce a much broader and balanced response to a number of the subdominant epitopes as well. The vaccination with peptide mix induces a T-cell response that includes response to subdominant epitopes is important for protection against chronic disease that on their own induces a response focused only on immunodominant epitopes.
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Patent Owner(s)
Patent Owner | Address | |
---|---|---|
STATENS SERUM INSTITUT | DK-2300 COPENHAGEN S |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
AAGAARD, CLAUS | Kobenhavn S, DK | 14 | 45 |
Andersen, Peter | Bronshoj, DK | 73 | 976 |
Dietrich, Jes | Kobenhavn NV, DK | 8 | 25 |
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