PROCESS FOR THE SYNTHESIS OF PRODRUGS OF OPIOIDS
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United States of America Patent
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Issued Date -
Jun 28, 2012
app pub date -
Dec 22, 2011
filing date -
Dec 23, 2010
priority date (Note) -
Abandoned
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Abstract
The present invention provides a process for the synthesis of opioid prodrugs. In particular, the present invention provides a process for the synthesis of opioid prodrugs comprising: treating an opioid, in the form of a salt or a freebase, with a carbonyl synthon to form an activated intermediate and subsequently reacting the activated intermediate with an amine, in the form of a salt or a freebase.
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