METHODS AND COMPOSITIONS FOR INHIBITING C-MET DIMERIZATION AND ACTIVATION

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United States of America Patent

PATENT NO 20120171210
APP PUB NO 20120171210A1
SERIAL NO

13371172

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by regulating c-met dimerization and/or binding of ligand to c-met using a c-met antagonist that disrupts c-met multimerization.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
GENENTECH, INC.SOUTH SAN FRANCISCO, CA2033

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kong-Beltran, Monica San Mateo, US 7 43
Wickramasinghe, Dineli M San Francisco, US 6 42

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Patent Info (Count) # Cites Year
 
Genentech, Inc. (2)
* 2009/0226,443 COMBINATION THERAPY WITH C-MET AND EGFR ANTAGONISTS 18 2009
9487589 Anti-c-met-antibody formulations 0 2014
 
ONCOMED PHARMACEUTICALS, INC. (1)
9168300 MET-binding agents and uses thereof 0 2014
* Cited By Examiner