PRODUCTION OF VIRAL CAPSIDS
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United States of America Patent
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Issued Date -
Jul 5, 2012
app pub date -
Jun 15, 2010
filing date -
Jun 15, 2009
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention provides methods of producing “empty” RNA virus capsids (e.g. from Cowpea mosaic virus) by assembly of viral small (S) and large (L) coat proteins in such a way that encapsidation of native viral RNA is avoided. Aspects of the invention employ in planta expression of capsid components from DNA vectors encoding the S and L proteins or S-L polyproteins including them. Such capsids have utility for the encapsidation or presentation of foreign proteins or desired payloads.
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