Co-Processed Excipient Compositions
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United States of America Patent
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Issued Date -
Jul 12, 2012
app pub date -
Apr 26, 2010
filing date -
Apr 28, 2009
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Abstract
An oral solid dosage form having improved dissolution profile and a method of producing the same are provided. The present invention particularly provides a co-processed excipient composition and a method of producing the same. More particularly, it relates to a co-processed binary mixture of crosslinked polyvinylpyrrolidone and calcium silicate; wherein the weight ratio of crosslinked polyvinylpyrrolidone and calcium silicate is in the range of 1:1 to 20:1. The binary mixture when combined with a poorly soluble drug enhances its dissolution and extent of release.
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