CHELATION OF METALS TO THIOL GROUPS USING IN SITU REDUCTION OF DISULFIDE-CONTAINING COMPOUNDS BY PHOSPHINES

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United States of America Patent

APP PUB NO 20120178906A1
SERIAL NO

13423751

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Abstract

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A method is disclosed for the syntheses of thiol-containing radiopharmaceuticals without the need for purification starting from chelators containing disulfide bonds. This is done by providing a method that reduces disulfide bonds on a precursor molecule or a precursor compound in the presence of phosphine compounds, thus freeing thiols for metal complexation.

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BRACCO IMAGING S P A20134 MILANO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cagnolini, Aldo Edison, US 6 44
Fan, Hong (Helen) Shanghai PuDong, CN 9 49
Linder, Karen E Kingston, US 53 1075
Ramalingam, Kondareddiar Stockbridge, US 62 960

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