GALANTAMINE AMINO ACID AND PEPTIDE PRODRUGS AND USES THEREOF
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United States of America Patent
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Issued Date -
Jul 19, 2012
app pub date -
Jul 23, 2010
filing date -
Jul 23, 2009
priority date (Note) -
Abandoned
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Abstract
Prodrugs of galantamine or its 3-hydroxy metabolite with amino acids or short peptides, pharmaceutical compositions containing such prodrugs and methods for treating a memory or cognition disorder with the galantamine prodrugs are provided herein. Prodrugs having side chains of valine, phenylalanine, tyrosine or para amino benzoic acid and mono-, di- and tripeptides thereof are preferred. Additionally, methods for avoiding or minimizing the adverse gastrointestinal side effects associated with galantamine administration, as well as improving the pharmacokinetics of galantamine are provided herein.
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