US Patent Application No: 2012/0189,540

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IL3Ralpha Antibody Conjugates And Uses Thereof

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Abstract

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The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3Rα) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3Rα-expressing cell population, the methods comprising contacting a population of IL3Rα-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3Rα. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3Rα chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3Rα-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3Rα.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
STEMLINE THERAPEUTICS, INC.NEW YORK, NY1

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bergstein, Ivan New York, NY 29 244

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