GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCED IN GLYCOENGINEERED PICHIA PASTORIS

United States of America Patent

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Issued Date
Aug 23, 2012
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Oct 25, 2010
filing date
Oct 30, 2009

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Abstract

Compositions comprising granulocyte-colony stimulating factor (GCSF) produced in a strain of Pichia pastoris glycoengineered to produce a GCSF wherein greater than 18% of the molecules comprise an 0-glycan with one mannose per (0-glycan is described. In particular aspects, the GCSF is PEGylated at the JV-terminus.

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MERCK SHARP & DOHME CORP	126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor Name	Address	# of filed Patents	Total Citations
Bobrowicz, Piotr	Hanover, US	49	760
Gomathinayagam, Sujatha	Hanover, US	4	28
Li, Huijuan	Hanover, US	27	512
Meehl, Michael	Lebanon, US	7	87
Rios, Sandra	Lebanon, US	4	34

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GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCED IN GLYCOENGINEERED PICHIA PASTORIS

Number of patents in Portfolio can not be more than 2000

United States of America Patent

13504528

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13504528

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