CYSTATIN C AS AN ANTAGONIST OF TGF-BETA AND METHODS RELATED THERETO

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United States of America Patent

APP PUB NO 20120214233A1
SERIAL NO

13248539

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed are Cystatin C (CysC) homologues, including CystC homologues that act as antagonists or inhibitors of transforming growth factor-β (TGF-β). Also disclosed are methods to identify CystC homologues that are antagonists or inhibitors of TGF-β and compositions and therapeutic methods using CystC and homologues thereof to regulate the activity of TGF-β, and TGF-β-mediated tumor malignancy and invasion and other TGF-β-mediated fibrotic or proliferative conditions and diseases.

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Patent Owner(s)

  • NATIONAL JEWISH HEALTH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Schiemann, William P Denver, US 9 48

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