ASSAY SYSTEMS FOR DETECTION OF ANEUPLOIDY AND SEX DETERMINATION
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United States of America Patent
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Issued Date -
Aug 30, 2012
app pub date -
Feb 27, 2012
filing date -
Feb 28, 2011
priority date (Note) -
Abandoned
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Abstract
The present invention utilizes detection of selected nucleic acid regions from pseudoautosomal regions to identify sex chromosomal aneuploidy and to determine fetal sex. Traditional methods of detecting sex chromosomal aneuploidies and performing sex determination typically involves some analysis of the Y chromosome. The assay systems of the present invention utilizing copy number variant detection of pseudoautosomal regions allows quantification of the sex chromosomes in mixed samples using loci that display autosomal inheritance patterns.
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