SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL TERT-BUTYL ESTERS OF PEPTIDES

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United States of America Patent

SERIAL NO

13474125

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Abstract

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The present invention relates to a process for the selective enzymatic hydrolysis of C-terminal esters of peptide substrates in the synthesis of peptides, comprising hydrolysing C-terminal tert-butyl esters using the protease subtilisin. This process is useful in the production of protected or unprotected peptides.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME B V2031 BN HAARLEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boeriu, Carmen G Wageningen, NL 2 0
Eggen, Ivo Franci Oss, NL 10 28

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