type 5 and type 8 capsular polysaccharides

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United States of America Patent

PATENT NO 8974799
SERIAL NO

13499238

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Abstract

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The invention provides a process for preparing a conjugate of a S. aureus type 5 or type 8 capsular polysaccharide and a carrier molecule, comprising the steps of: (a) depolymerizing the capsular polysaccharide, to give a polysaccharide fragment; (b) oxidizing the fragment in order to introduce an aldehyde group into at least one saccharide residue in the fragment, to give an oxidized saccharide residue; and (c) coupling the oxidized saccharide residue to a carrier molecule via the aldehyde group, thereby giving the conjugate. The coupling in step (c) may be direct, or may be via a linker molecule. The invention also provides a conjugate obtained or obtainable by this process.

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Patent Owner(s)

  • SMITHKLINE BEECHAM BIOLOGICALS S.A.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berti, Francesco Colle Val d' Elsa, IT 50 165
Costantino, Paolo Colle Val d' Elsa, IT 53 322
Romano, Maria Rosaria Pontedera, IT 20 53

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