CROSS-SPECIES-SPECIFIC BISPECIFIC BINDERS
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United States of America Patent
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Issued Date -
Sep 27, 2012
app pub date -
Feb 29, 2012
filing date -
Apr 3, 2007
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a polypeptide comprising a first human binding domain capbable of binding to an epitope of human and non-chimpanzee CD3ε (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acid sequences encoding the polypeptide, to vectors comprising the nucleic acid sequences and to host cells comprising the nucleic acid sequences or vectors containing the nucleic acid sequences. In another aspect, the invention provides for a pharmaceutical composition comprising the polypeptide and methods of medical treatment or use of the polypeptide.
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