Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts

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United States of America Patent

PATENT NO 10106788
APP PUB NO 20120245036A1
SERIAL NO

13298559

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Abstract

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The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.

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Patent Owner(s)

Patent OwnerAddress
BIOATLA INC11085 TORREYANA ROAD SUITE 100 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Short, Jay Milton Del Mar, US 7 22

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