INHIBITORS OF THAPSIGARGIN-INDUCED CELL DEATH
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United States of America Patent
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Issued Date -
Sep 27, 2012
app pub date -
Apr 19, 2012
filing date -
May 25, 2007
priority date (Note) -
Abandoned
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Abstract
Methods for screening for inhibitors of endoplasmic reticulum (ER) stress are provided. These methods involve the addition of thapsigargin, which induces ER stress, and a test agent to mammalian cells in multi-well plates. Cell survival can be readily monitored by measuring intracellular ATP content using a bioluminescent reagent. Screening a commercially available library of 50,000 compounds led to the identification of 93 hit compounds that were subjected to secondary assays to confirm their ability to rescue cells from thapsigargin-induced cell death.
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