Screening Assay for Bladder Cancer
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United States of America Patent
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Issued Date -
Oct 4, 2012
app pub date -
May 15, 2012
filing date -
Aug 17, 2007
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention generally relates to methods of screening for cancer. Methods of the invention involve identifying a threshold parameter of a protein and of two or more nucleic acids, where the threshold parameters are indicative of the absence of cancer, conducting an assay in a sample to determine a parameter of the two or more nucleic acids and a parameter of the protein, and identifying the sample as positive for cancer if the parameters of at least one of the nucleic acids and the protein present in the sample are greater than their respective threshold parameters. In certain aspects of the invention, the nucleic acids include FGFR3, p53, TWIST1, Vimentin, and NID2. In certain aspects of the invention, the protein includes MMP2 or MMP9.
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