PROCESS FOR MANUFACTURING CONJUGATES OF IMPROVED HOMOGENEITY
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United States of America Patent
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Issued Date -
Oct 11, 2012
app pub date -
Mar 29, 2012
filing date -
Mar 29, 2011
priority date (Note) -
Abandoned
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Abstract
The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved homogeneity comprising performing the modification reaction at a lower temperature. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent at a temperature of about 15° C. or less to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto.
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