LYMPHOCYTE ANALYSIS FOR MONITORING THE PROGRESSION OF IMMUNODEFICIENCY VIRUS
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United States of America Patent
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Issued Date -
Oct 18, 2012
app pub date -
Mar 28, 2012
filing date -
Apr 12, 2011
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present disclosure describes a method of monitoring disease progression in a mammal positive for immunodeficiency virus which includes collecting blood cells from a mammal to obtain a first blood sample adding antibodies such as CD4 and CD8 to the first blood sample scanning the blood sample to produce a first multivariate dot plot which may be used to quantify at least CD4+ and CD8+ blood cell populations to produce a first ratio. The first multivariate dot plot may also be used to quantify a CD8αβlow subpopulation which may be used to calculate a second ratio. A third ratio is calculated of the second ratio to the first ratio and the result plotted on a graph as a first point. This process may be repeated to produce a second point for evaluating an extent of disease progression.
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