AUTOMATED PAP SCREENING USING A PLURALITY OF BIOMARKERS AND MULTI-SPECTRAL IMAGING
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United States of America Patent
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Issued Date -
Oct 18, 2012
app pub date -
Mar 29, 2012
filing date -
Apr 12, 2011
priority date (Note) -
Abandoned
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Abstract
An automated screening method for detecting abnormalities in a sample. The method includes steps of staining a sample with a histologic or cytologic stain for transmission light microscopy to provide a stained sample; exposing the stained sample to a plurality of differentially-labeled biomarkers, wherein each of the biomarkers is labeled with a distinct transmission stain or fluorescence probe; at a first location, generating at least one multi-spectral image of the stained sample using signals obtained from the plurality of differentially-labeled biomarkers and the histologic or cytologic stain; and automatically determining whether the first location requires further pathologist review or interpretation.
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