Glycosylated Form of Antigenic GLP-1 Analogue
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United States of America Patent
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Issued Date -
Oct 18, 2012
app pub date -
Oct 25, 2010
filing date -
Oct 30, 2009
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Abandoned
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Abstract
Disclosed is a glucagon-like peptide-1 (GLP-1) analogue which is obtained by ameliorating a highly antigenic GLP-1 analogue so that the GLP-1 analogue has reduced antigenicity without being lowered in the blood glucose suppressing activity. Specifically disclosed is a glycosylated form of an antigenic GLP-1 analogue, which has GLP-1 activity and is obtained by substituting at least one amino acid of an antigenic GLP-1 analogue with a glycosylated amino acid.
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