METHOD FOR SAMPLE ANALYSIS OF ANEUPLOIDIES IN MATERNAL SAMPLES
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United States of America Patent
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Issued Date -
Oct 25, 2012
app pub date -
May 29, 2012
filing date -
Jan 19, 2010
priority date (Note) -
Abandoned
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Abstract
The invention provides methods for determining aneuploidy and/or fetal fraction in maternal samples comprising fetal and maternal cfDNA by massively parallel sequencing. The method comprises a novel protocol for preparing sequencing libraries that unexpectedly improves the quality of library DNA while expediting the process of analysis of samples for prenatal diagnoses. The novel protocol can be performed in solution or on a solid surface.
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Family
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