Mutant Sodium Channel Nav1.7 and Methods Related Thereto
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United States of America Patent
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Issued Date -
Nov 8, 2012
app pub date -
Sep 13, 2010
filing date -
Sep 11, 2009
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Abandoned
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Abstract
Described are mutant Nav1.7 sodium channel alpha-subunits and nucleic acid sequences encoding such mutants. Further described are methods for characterizing a nucleic acid sequence that encodes a Nav1.7 sodium channel alpha-subunit, methods for determining a Nav1.7 haplotype, methods for determining a subject's predisposition to a neurologic disorder associated with a sodium channel mutation, and methods of identifying a compound that modulates mutant Nav1.7 sodium channels. Other materials, compositions, articles, devices, and methods relating to mutant Nav1.7 sodium channels are also described herein.
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