METHOD AND SYSTEM FOR ROBUST AND SENSITIVE ANALYSIS OF BEAD-BASED ASSAYS

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United States of America Patent

APP PUB NO 20120288849A1
SERIAL NO

13364302

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Abstract

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Computer-implemented methods and systems are provided for the analysis of multiplex fluorescent-dyed microsphere assays. The methods of the invention provide for determination of differences in analyte quantities between samples obtained from multiplex fluorescent-dyed microsphere assays by analysis of individual bead fluorescence and adjusting for variance; variance-stabilization of the data, and determining significance with hypothesis testing with tolerance determined by power estimation. The methods of the invention provide a benefit in allowing access to low signal or poor quality data, increased statistical power and decreased variability compared to standard curve methodology.

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Patent Owner(s)

Patent OwnerAddress
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYSTANFORD CA 94305-2038

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davis, Mark M Atherton, US 42 573
Goldberger, Ofir Menlo Park, US 1 1
Olshen, Richard A Stanford, US 3 77
Won, Joong-Ho Cupertino, US 1 1

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