METHOD AND KIT FOR MEASURING ENZYMATIC ACTIVITIES OF VARIOUS CYTOCHROME P450 MOLECULE SPECIES COMPREHENSIVELY AND WITH HIGH EFFICIENCY
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United States of America Patent
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Issued Date -
Nov 15, 2012
app pub date -
Aug 27, 2010
filing date -
Sep 1, 2009
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a method, and a kit, for measuring the enzymatic activity of cytochrome P450 comprehensively and with high efficiency and accuracy, wherein an oxygen sensing layer and a cytochrome P450-supporting layer are vertically integrated on a chip, and cytochrome P450 is supported in a hydrophilic polymer matrix in the cytochrome P450-supporting layer,
- the cytochrome P450 generates NADPH by being irradiated with light in the presence of at least one caged compound selected from the group consisting of caged-NADP and caged-G6P, an enzyme utilizing NADPH as a coenzyme (i.e., cytochrome P450 reductase) and a substrate thereof to supply NADP and/or G6P from the caged compound to generate NADPH to start the reaction between the enzyme and a substrate.
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