COMPARATIVE LIGAND MAPPING FROM MHC CLASS I POSITIVE CELLS
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United States of America Patent
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Issued Date -
Nov 29, 2012
app pub date -
Nov 23, 2010
filing date -
Oct 10, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules which may be uninfected, infected, or tumorgenic. The methodology of the present invention broadly allows for these peptide ligands and their comcomittant source proteins thereof to be identified and used as markers for infected versus uninfected cells and/or tumorgenic versus nontumorgenic cells with said identification being useful for marking or targeting a cell for therapeutic treatment or priming the immune response against infected cells.
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