Methods and compositions for gene inactivation
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United States of America Patent
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Sep 3, 2013
Grant Date -
Dec 6, 2012
app pub date -
May 5, 2011
filing date -
May 25, 2006
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Abstract
Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.
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