CHRONIC INFLAMMATION AND TRANSPLANTATION
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United States of America Patent
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Issued Date -
Dec 6, 2012
app pub date -
Jan 20, 2012
filing date -
Dec 31, 2007
priority date (Note) -
Abandoned
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Abstract
Embodiments of the present invention feature methods for treating inflammatory disease and transplantation characterized in that it includes: (i) the incubation of organs with one or more Bryostatin-1 derivatives under conditions which permits vascular exposure to these compounds prior to or immediately following organ ‘harvesting’, and (ii) intravenous, transdermal, intraperitoneal, intra-alveolar instillation of Bryostatin-1 in vivo during active disease, or during periods of disease remission and (iii) prophylactic administration of Bryostatin-1 to limit the development of GVHD.
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