METHODS FOR AFFINITY MATURATION-BASED ANTIBODY OPTIMIZATION
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United States of America Patent
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app pub date -
Nov 4, 2010
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Nov 4, 2009
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Abstract
Provided herein is a rational method of affinity maturation to evolve the activity of an antibody or portion thereof based on the structure/affinity or activity relationship of an antibody. The resulting affinity matured antibodies exhibit improved or optimized binding affinity for a target antigen.
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