COMPOSITIONS AND USES
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United States of America Patent
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N/A
Issued Date -
Dec 20, 2012
app pub date -
May 1, 2012
filing date -
Oct 27, 2010
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
Compositions and methods comprising or using a combination of an adjuvant such as AS01B and an antigen such as a β-amyloid antigen are provided. The compositions and methods provided are particularly useful for prevention or treatment of Alzheimer's disease. Suitable β-amyloid antigens are Aβ1-5, Aβ1-6, Aβ1-7, Aβ1-10, Aβ1-14, Aβ1-15, Aβ2-7, Aβ2-8, Aβ3-7, Aβ3-8, Aβ11-16, Aβ11-17, Aβp(E)3-7, Aβp(E)3-8, Aβp(E)3-40, Aβp(E)3-42, Aβp(E)11-16, Aβp(E)11-17, Aβp(E)11-40 or Aβp(E)11-42, optionally with a protein carrier. Suitable adjuvants comprise QS21, 3D-MPL or an AGP, optionally in combination with a liposome.
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