POLY-PEGYLATED PROTEASE INHIBITORS
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United States of America Patent
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Issued Date -
Dec 20, 2012
app pub date -
May 3, 2012
filing date -
Aug 29, 2003
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine of the Kunitz domain polypeptide can be attached to one of the moieties. Also disclosed are related methods.
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