EPIGENETIC DNA ENRICHMENT
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United States of America Patent
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Issued Date -
Dec 27, 2012
app pub date -
Oct 13, 2010
filing date -
Oct 14, 2009
priority date (Note) -
Abandoned
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Abstract
This application relates to methods for enriching DNA from a first cell type from a sample comprising DNA from the first cell type and DNA from a second cell type, wherein the first cell type methylates DNA to a lesser extent than the second cell type. DNA is enriched by, selecting for fragments by size after digestion of the sample with a methylation-sensitive restriction enzyme. Cell types of interest include fetal cells and cancerous cells. The enriched DNA can be used for a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.
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