BRAF mutations conferring resistance to BRAF inhibitors
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United States of America Patent
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Jan 28, 2014
Grant Date -
Jan 3, 2013
app pub date -
Feb 22, 2011
filing date -
Feb 25, 2010
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Abstract
The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of BRAF. In particular embodiments, the invention concerns mutations in a BRAF sequence that confer resistance to a BRAF inhibitor. Identification of such mutations in a BRAF sequence allows the identification and design of second-generation BRAF inhibitors. Methods and kits for detecting the presence of a mutant BRAF sequence in a sample are also provided.
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