CONTROLLED RELEASE OXYCODONE COMPOSITIONS

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United States of America Patent

SERIAL NO

13604066

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Abstract

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A method for preparing a solid oral dosage form comprising up to about 160 mg of oxycodone or a salt thereof to control pain in substantially all patients is disclosed. The method comprises wet granulating at least one hydrophilic or hydrophobic polymer, preferably a hydroxyalkyl cellulose or an alkyl cellulose, with oxycodone or a salt thereof to form a controlled-release matrix. Repeated “q12h” (i.e., every 12 hour) administration of the dosage form through steady-state conditions results in a mean maximum plasma concentration of oxycodone up to about 240 ng/ml from a mean of about 2 to about 4.5 hours after administration, and a mean minimum plasma concentration up to about 120 ng/ml from about 10 to about 14 hours after administration.

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Patent Owner(s)

Patent OwnerAddress
PURDUE PHARMA L PU S A

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chasin, Mark Manalpan, US 116 12920
Francis, Kaiko Robert Weston, US 5 102
Minogue, John Joseph Mount Vernon, US 18 775
Oshlack, Benjamin New York, US 246 21355

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