SUBSETS OF ANTIGEN-PRESENTING CELLS (APCs) IN THE HUMAN VAGINA AND THEIR DISTINCT FUNCTIONS
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United States of America Patent
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Issued Date -
Jan 17, 2013
app pub date -
Jul 11, 2012
filing date -
Jul 11, 2011
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Abstract
Compositions and methods for generating dendritic cell (DC)-targeting vaccines against vaginal infections, including but not limited to sexually transmitted diseases, are disclosed herein. The present invention reports the isolation of at least four major subsets of myeloid-originated antigen-presenting cells (APCs) that possess distinct phenotypes and functions in directing immune responses, namely, Langerhans cells (LCs: E-cadherin+CD207+CD205+), CD1c+CD14− DCs (DC-ASGPR+CD209+/−Dectin-1+/−), and CD1c+CD14+ DCs (CD209+/−DC-ASGPR+/−) all expressing high levels of CD11c, CD83, and CCR6, and are more potent than CD1c−CD14+ macrophages (CD163+CD209+DC-ASGPR+/−Dectin-1+/−LOX-1+CD1d+) at eliciting naïve T cell proliferation The compositions, methods and vaccines of the present invention are directed towards the four functionally distinct major subsets of antigen-presenting cells (APCs) that can differentially contribute to the host immune response in the female genital tract, including the vagina.
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