Biosensor electrode mediators for regeneration of cofactors
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United States of America Patent
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Apr 9, 2013
Grant Date -
Feb 7, 2013
app pub date -
Jul 30, 2012
filing date -
Oct 16, 1997
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Abstract
The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
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