Medical device with coating that promotes endothelial cell adherence

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9072723
APP PUB NO 20130035755A1
SERIAL NO

13589907

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.

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Patent Owner(s)

  • ORBUSNEICH MEDICAL, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cottone,, Jr Robert J Davie, US 8 17
Kutryk, Michael John Bradley Ontario, CA 11 285
Rowland, Stephen M Miami, US 26 2398

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