Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
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United States of America Patent
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Oct 27, 2020
Grant Date -
Feb 14, 2013
app pub date -
Jul 31, 2012
filing date -
Oct 5, 2006
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Abstract
Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
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