Method of sensitizing cancer cells to the cytotoxic effects of death receptor ligands in cancer treatment
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United States of America Patent
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Jan 19, 2016
Grant Date -
Feb 14, 2013
app pub date -
Dec 16, 2010
filing date -
Dec 16, 2009
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Abstract
Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor ligand in conjunction with an effective amount of a compound described herein, for example, a cucurbitacin (I) or a withanolide (II). Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with a compound described herein, for example, a cucurbitacin (I) or a withanolide (II) and also contacting the cancer cells with a death receptor ligand, whereby apoptosis is induced in the cancer cells.
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