METHODS TO FORM SUBSTRATES FOR OPTICAL SENSING BY SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) AND SUBSTRATES FORMED BY THE METHODS
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United States of America Patent
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Issued Date -
Feb 21, 2013
app pub date -
Aug 17, 2012
filing date -
Aug 19, 2011
priority date (Note) -
Abandoned
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Abstract
A method of manufacturing a substrate is provided. The method comprises, in some aspects, a) providing a support; b) forming a template by attaching a plurality of polymeric nanoparticles some or all having a core-shell structure to the support, wherein the core comprises a first polymer and the shell comprises a second polymer; and c) forming the metal nanoarray substrate by attaching a plurality of metallic nanoparticles to at least some of the polymeric nanoparticles of the template. A biosensor comprising a substrate manufactured by the method, and a method for the detection of an analyte in a sample by surface enhanced Raman spectroscopy (SERS) is also provided.
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