Compositions and Methods for Enhancing Proteasome Activity
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United States of America Patent
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Issued Date -
Feb 21, 2013
app pub date -
Jan 28, 2011
filing date -
Jan 28, 2010
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Abstract
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp 14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
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