Methods of Producing Adenovirus Vectors and Viral Preparations Generated Thereby
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United States of America Patent
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Feb 28, 2013
app pub date -
Jan 12, 2011
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Jan 12, 2010
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Abstract
The present invention, in some embodiments thereof, relates to methods of producing adenoviruses such as pro- and anti-angiogenic adenovirus vectors and preparations generated thereby. Particularly, in some embodiments, the viral vectors comprise a heterologous pro- or anti-angiogenic gene under the transcriptional control of the murine pre-proendothelin promoter (e.g. PPE-1-3X), for targeted expression of in angiogenic endothelium.
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