INNOCULATION OF RECOMBINANT VIRAL VECTORS FOR RAPID PRE-EXPOSURE PREVENTION AND POST-EXPOSURE PROTECTION AGAINST ALPHAVIRUS-INDUCED ENCEPHALITIDES

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United States of America Patent

SERIAL NO

13564301

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Abstract

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This invention addresses how to rapidly prevent alphavirus-induced encephalitides before and after exposure to alphaviruses. The invention discloses a single dose administration of two types of recombinant viral vectors: one expressing interferon and another expressing the structural proteins of alphaviruses or a single dose administration of the recombinant viral vector co-expressing both interferon and the structural proteins of alphaviruses. This invention can be used to prevent humans from alphavirus-induced encephalitides in the event of a bioterrorism attack or biowarfare in which alphaviruses such as Venezuelan (VEEV), eastern (EEEV) and western (WEEV) equine encephalitis viruses are deliberately released to humans, a natural outbreak of alphaviruses, and an accidental exposure to alphaviruses in laboratory.

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Patent Owner(s)

Patent OwnerAddress
HER MAJESTY THE QUEEN IN RIGHT OF CANADA AS REPRESENTED BY THE MINISTER OF NATIONAL DEFENCEOTTAWA ON K1A 0K2

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nagata, Leslie P Medicine Hat, CA 13 118
Wu, Josh Qiaohua Medicine Hat, CA 2 1

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