Molecular testing of multiple pregnancies

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10900080
APP PUB NO 20130059733A1
SERIAL NO

13405073

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Abstract

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Methods, systems, and apparatus are provided for determining zygosity of a multiple-fetus pregnancy using a biological sample taken from the mother. The fetal and maternal DNA in the sample (e.g. plasma) can be analyzed for a particular chromosomal region to identify genetic differences in the fetuses. For example, a normalized parameter for the measure of a primary or secondary allele can show variances for different chromosomal regions when fetuses are dizygotic. Such a variance can be determined relative to an expected value if the fetuses were genetically identical. Statistical methods are provided for analyzing the variation of the normalized parameters to determine fetal DNA concentration and the maternal-fetal mixed genotype at various loci. Parental genotype and haplotype information can also be used to identify inheritance of different parental haplotypes to indicate genetic differences among the fetuses.

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Patent Owner(s)

  • THE CHINESE UNIVERSITY OF HONG KONG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chan, Kwan Chee Mei Foo Sun Chuen, HK 129 2849
Chu, Wai Kwun Rossa Shatin, HK 1 10
Jiang, Peiyong Shatin, HK 86 751
Leung, Tak Yeung Shatin, HK 3 10
Lo, Yuk Ming Dennis Homantin, HK 69 2762

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