EGF RECEPTOR MIMICKING PEPTIDES
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United States of America Patent
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Issued Date -
Mar 7, 2013
app pub date -
Feb 8, 2011
filing date -
Feb 8, 2010
priority date (Note) -
Abandoned
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Abstract
Provided are peptides which can mimic the epidermal growth factor receptor (EGFR), e.g., by selectively binding TGF-α and/or EGF. In certain embodiments, the peptides are retro-inverted peptides. The peptides may be used as soluble decoys for TGF-α and/or EGF, and anti-cancer properties of peptides are demonstrated both in vitro and in vivo. The peptides may be administered alone or comprised in a fusion construct, imaging construct, and/or a therapeutic construct, e.g., for the treatment of a cancer.
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